Polling stations across Gorton & Denton are now open after a month of fierce campaigning in the North West.
The vote was triggered by the resignation of Andrew Gwynne, who was sitting as an independent following his suspension from Labour last February.
Mr Gwynne won the seat in 2024 with more than half the vote - but had the whip removed after his offensive messages on WhatsApp came to light.
Greater Manchester Mayor Andy Burnham had been widely tipped to step up and stand for Labour - but the Prime Minister's allies blocked him from having a go.
Today will only be the second parliamentary by-election during Sir Keir Starmer's time in No10 after Runcorn & Helsby on May 1 last year.
A total of 11 candidates are standing on February 26.
Polling stations opened at 7am, and will close at 10pm.
The result is expected in the early hours of Friday morning - and GB News will bring you the very latest coverage into the night.
FOLLOW BELOW FOR LIVE UPDATES THROUGHOUT THE DAY...
Labour minister slams Kemi Badenoch's 'paedo defenders party' jibe
A minister has criticised Kemi Badenoch’s decision to describe Labour as a "paedo defenders party" during Prime Minister’s Questions.
The opposition leader’s jibe followed reporting by The Times that female Labour MPs had told Sir Keir earlier this month that voters had "screamed" the phrase at them in the street over the Peter Mandelson scandal.
Communities minister Alison McGovern was asked her opinion on Mrs Badenoch’s use of the phrase.
She told LBC: "I think it’s not good. Yesterday in the House of Commons, when she used that language, I think there were lots of people on all sides of the House of Commons that felt that that’s not good.
"I would say we’ve seen this across all parties, where we need to remember that we as politicians are responsible for the words we say, and that we can debate issues in a very serious, robust and forthright way, without using the language that’s going to be inflammatory and make the whole situation of the challenges we are facing in communities much worse."
Senior Tory calls for 'culture of openness' amid damning NHS maternity report
James Cartlidge speaking on GB News this morning
|GB NEWS
A senior Conservative has told GB News there needs to be a "culture of openness" in the NHS after a damning report into maternity services.
An interim report published by Baroness Amos as part of her National Maternity and Neonatal Investigation found deep-rooted issues across the NHS and a system that "is not working for women, babies and families, or for staff."
Shadow Defence Secretary James Cartlidge told GB News: "The key issue is about being transparent particularly with parents. It's a very stressful situation.
"I'm a father of four. When you go into maternity wards, it is such a crucial moment in life. It causes a lot of anxiety, especially if there are complications.
"You want parents to have access to all information about what is happening. That's what I'm concerned about.
"My colleagues from the Shadow Health team will be all over this when the report is fully released. There has been a culture in the NHS of not being open enough."
Yvette Cooper to announce new minerals deal with Kazakhstan today
Yvette Cooper is set to announce a new minerals deal with Kazakhstan later today as the West tries to its supply chains away from Beijing.
The Foreign Secretary is hosting her counterparts from Kazakhstan, Kyrgyzstan, Tajikistan, Turkmenistan, Uzbekistan at Lancaster House in London.
She will confirm the deal with her Kazakh counterpart Yermek Kosherbayev, alongside pacts with the other countries covering carbon capture and higher education.
The Foreign Secretary told Politico: "Central Asia is an important region with huge potential to boost economic growth.
"These agreements deliver for British businesses, strengthen economic security and are a clear demonstration of UK support for the independence of the Central Asian states."
Rachel Reeves now demands Andrew Mountbatten-Windsor repay taxpayer cash he 'misused to spend on massages'
Rachel Reeves now demands Andrew Mountbatten-Windsor repay taxpayer cash he 'misused to spend on massages' | PA
Rachel Reeves has urged Andrew Mountbatten-Windsor to repay taxpayer cash he may have misused while serving as Britain's trade envoy.
The ex-prince has faced allegations of misusing taxpayer money in a number of ways in his role between 2001 and 2011, including on massages, "unreasonable" numbers of hotels, and taxpayer-funded aircraft on RAF bases.
Mr Mountbatten-Windsor was arrested last week on suspicion of misconduct in public office and was released without charge.
Our reporter Peter Stevens has the story here.
Your Party to announce leadership later today
Jeremy Corbyn’s Your Party will announce its first leaders on Thursday following a foundation process fraught with infighting.
The announcement at 11am will see a 24-strong central executive committee (CEC) elected to lead the party in place of the single leader favoured by other parties.
The CEC includes 20 seats for ordinary party members elected on a regional basis, plus another four elected from among Your Party’s "public office holders" such as MPs and councillors.
While most of those elected will be ordinary members, the contest has been seen as a battle between Mr Corbyn and former Labour MP Zarah Sultana for control of the party.
RECAP: How was Andy Burnham blocked from standing?
Andy Burnham was blocked from seeking the Labour nomination by the NEC | PAA month ago, Sir Keir Starmer's allies blocked Greater Manchester Mayor Andy Burnham from standing in Gorton & Denton.
Eight of the Labour National Executive Committee's (NEC's) 10 members — including the Prime Minister himself — voted against Mr Burnham standing in the seat, vacated by outgoing MP Andrew Gwynne.
Just one committee member was in favour, the party's deputy leader Lucy Powell - while the NEC chairman, Home Secretary Shabana Mahmood, abstained.
In a statement, Labour said: "The NEC believes that causing an unnecessary election for the position of Greater Manchester Mayor would have a substantial and disproportionate impact on party campaign resources ahead of the local elections and elections to the Scottish Parliament and Welsh Senedd in May.
"Although the Party would be confident of retaining the mayoralty, the NEC could not put Labour’s control of Greater Manchester at any risk.
"Andy Burnham is doing a great job as Mayor of Greater Manchester. We believe it is in the best interests of the party to avoid an unnecessary Mayoral election which would use substantial amounts of taxpayers’ money and resources that are better spent tackling the cost of living crisis."
REMINDER: Who is standing in today's Gorton & Denton by-election?
Standing to replace Andrew Gwynne in the Commons for Gorton & Denton are the following candidates:
Sir Oink A-Lot - The Official Monster Raving Loony Party
Nick Buckley - Advance UK
Charlotte Cadden - Conservative Party
Dan Clarke - Libertarian Party
Matt Goodwin - Reform UK
Sebastian Moore - Social Democratic Party
Joseph O'Meachair - Rejoin EU
Jackie Pearcey - Liberal Democrats
Hannah Spencer - Green Party
Angeliki Stogia - Labour Party
Hugo Wils - Communist League Election Campaign
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