Tatiana Schlossberg, the granddaughter of President John F Kennedy, has died at the age of 35 following a battle with blood cancer.
The JFK Library Foundation confirmed her passing on Tuesday morning through a statement posted on Instagram.
"Our beautiful Tatiana passed away this morning," the message read. "She will always be in our hearts."
The tribute was signed by her husband George, their two children Edwin and Josephine, as well as her parents and siblings.
Tatiana Schlossberg, the granddaughter of President John F Kennedy, has died at the age of 35
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Ms Schlossberg was the daughter of Caroline Kennedy, who served as US ambassador, and designer Edwin Schlossberg.
Her death comes merely six weeks after she publicly disclosed her terminal cancer diagnosis in an essay for The New Yorker magazine.
Medical professionals discovered Ms Schlossberg's illness in May 2024 through routine blood tests conducted after she delivered her second child.
The 35-year-old had been diagnosed with acute myeloid leukaemia, a form of blood cancer, despite experiencing no symptoms whatsoever.
Tatiana Schlossberg has died at 35
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Writing about her diagnosis, she expressed disbelief at the news, stating: "I did not - could not - believe that they were talking about me."
Ms Schlossberg described herself as being in excellent physical condition prior to the discovery, having swum a mile whilst nine months pregnant just the day before her diagnosis.
"I wasn't sick. I didn't feel sick. I was actually one of the healthiest people I knew," she wrote.
The cancer was found to be acute myeloid leukaemia with a rare mutation, requiring immediate and intensive treatment.
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Tatiana Schlossberg was John F Kennedy's granddaughter
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Her treatment regimen included multiple rounds of chemotherapy and two stem cell transplants, alongside participation in clinical trials.
Ms Schlossberg's sister Rose proved to be a compatible donor, providing stem cells for her initial transfusion.
Her brother Jack, though only a half-match, remained determined to help, questioning doctors about whether a partial match might somehow prove more effective.
In her New Yorker essay, Ms Schlossberg described receiving unwavering support from her parents, as well as from Rose and Jack, throughout the gruelling months of treatment.
Tatiana Schlossberg
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Her cousin Kerry Kennedy, speaking just weeks ago, paid tribute to her bravery in sharing her story publicly.
"She was so incredibly brave to express herself, and right now we're all holding her in our hearts, and holding Caroline in our heart," Ms Kennedy said.
Ms Schlossberg, who worked as an environmental journalist, used her New Yorker piece to criticise her relative Robert F Kennedy Jr over his stance on vaccines.
She expressed concern that measures supported by RFK Jr, a prominent vaccine sceptic, could harm cancer patients like herself.
In her essay, she noted that he had cut nearly half a billion dollars from research into mRNA vaccines, technology with potential applications in cancer treatment.
The Kennedy family has endured considerable tragedy over the decades.
Ms Schlossberg's mother Caroline was just five days from her sixth birthday when President Kennedy was assassinated in Texas in 1963.
Three decades later, Caroline's only surviving sibling, John F Kennedy Jr, died in a plane crash.