Prince Harry refused to address the situation surrounding his uncle, Andrew Mountbatten-Windsor, in a question put to him during his trip to Jordan.
The duke, alongside his wife, Meghan Markle, undertook a two-day visit to humanitarian organisations in the region.
Harry and Meghan were seen hugging and comforting young cancer patients and their families during an emotional outing as part of their visit with the World Health Organisation (WHO).
The Duke of Sussex told Channel 4: "The world should be incredibly grateful for what Jordan is doing and the moral leadership it's showing for the world right now."
Harry has ignored questions about Andrew during his trip to Jordan
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Before the interview started, the Channel 4 reporter noted the ongoing situation with Harry's family in the UK, mentioning Andrew after he was arrested and released under investigation on suspicion of misconduct in public office.
The interviewer said: "I understand you don't wish to talk about your family, your uncle, things back in London you're here because you don't want to distract from the work you're doing on the WHO and on Gaza.
"Firstly, why are you here in Jordan? Why is it so important to you?"
Harry did not address the first part of the question, ignoring it in its entirety.
Harry ignored the Andrew section of the interviewer's question
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The duke said: "I think, having spoken to Dr Tedros [WHO Director-General, Dr Tedros Adhanom Ghebreyesus] for many months now, well, years, but specifically months in the lead-up to this trip, it was really important for us to highlight the incredible work that Jordan does for this region.
"The work's been going on for decades, but more so recently, it's been a humanitarian hub for the Middle East, especially with everything that's going on in Gaza, and also Syria, as well."
On the last day of their visit, the Duke and Duchess of Sussex journeyed to the King Hussein Cancer Centre.
Meghan met Huda Ramadan Alrhawjara and hugged her as she explained that her son, Mohammed, had suffered a recurrence of leukaemia during the conflict between Hamas and Israel in Gaza.
Harry and Meghan were invited to Jordan by Dr Tedros Adhanom Ghebreyesus, Director-General of WHO
| GETTYMs Alrhawjara told Meghan: "It doesn't matter if it takes four years, what matters is to have him healthy."
The mother and son were part of a group of young Palestinians from Gaza being treated at the centre.
She later said: "I'm really happy that the prince and his wife are really on the side of the families, and that they came to hear our stories, it shows their humanity."
The British Government sought to distance itself from the Duke and Duchess of Sussex's visit, following revelations that the couple attended an event at the British Ambassador's residence in Amman.
The Duke and Duchess of Sussex visited the King Hussein Cancer Centre on the last day of their visit
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Officials at the Foreign Office have refused to comment on the two-day Middle Eastern trip.
Sources familiar with the visit have clarified that Ambassador Phillip Hall did not extend a direct invitation to Harry and Meghan for the Iftar reception, which marks the evening meal breaking the Ramadan fast.
The Sussexes had announced in their own press statement that they "joined World Health Organisation officials and Embassy staff at the British Ambassador's residence for Iftar as day one closed with a renewed sense of urgency and resolve".
A source with knowledge of the arrangements has maintained that the British Government played no role in organising or supporting the Sussexes' trip, emphasising their status as "private citizens".
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