The Prime Minister's woes look set to worsen as a bombshell analysis shows the potential impact of offending Donald Trump.
Relations between the two leaders have become increasingly strained over the last few months.
Keir Starmer rolling out the red carpet for Emmanuel Macron earlier this summer upped the ante.
In what was read by many as an attempt to reset Britain's post-Brexit relationship with the EU, the French president was lavished with gold carriages, military bands, and a glittering state banquet at Windsor Castle, which boasted the biggest names in entertainment, such as Mick Jagger and Hugh Grant.
However, this attempt at rapprochement ruffled feathers across the Atlantic after it emerged that Donald Trump would not be granted the privilege of addressing Parliament during his state visit.
US commentators were up in arms, with GB News columnist Lee Cohen describing it as a "plot to silence President Donald Trump" that would backfire.
The Prime Minister has also been busy giving away sovereign territory such as the Chagos Peninsula, which is home to a US base, floating recognition of Palestine as a state at the UN next week and getting on the wrong side of the free speech debate - all of which risk incurring Donald Trump's wrath, analysts believe.
Now, an exclusive analysis by Stand for Our Sovereignty and Brexit Facts4EU concludes that snubbing the 47th President in favour of a closer relationship with the EU is economic suicide.
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The US is by far Britain's biggest export market
|FACTS4EU
The graph shown to GB News shows Uncle Sam is by far Britain's biggest export market.
Sir John Redwood, former Secretary of State, said: "The UK Government should welcome President Trump warmly by abandoning the expensive and dangerous idea of giving away the Chagos islands, including Diego Garcia - a key joint US/UK base.
"The money saved could be spent on a bigger UK contribution to Nato defence. The US is by far our biggest export market and biggest provider of inward investment.
"The PM needs to propose lower tariffs and more mutually beneficial business activity rather than picking fights over foreign policy with our most important ally.
"Facts4EU once again highlight the truth by showing how we need the US more than France for growth and defence."
Donald Trump has not been granted the privilege of addressing Parliament during his state visit
|PA
Prior to boarding Marine One on Tuesday, President Trump told reporters: "Basically I’m there also on trade. They want to see if they can refine the trade deal a little bit. We made a deal, and it’s a great deal, and I’m into helping them."
"They’d like to see if they could get a little bit better deal."
Britain and the United States agreed a technology pact to boost ties in AI, quantum computing and civil nuclear energy, with top US firms led by Microsoft pledging £31billion in UK investments.
The "Tech Prosperity Deal" is part of US President Donald Trump's second state visit to Britain.
It was revealed this week that the Prime Minister's favourability has plunged to the lowest point ever as he attempts to hold power within his own party
| PASir Keir said the deal had the potential to shape the future of millions of people on both sides of the Atlantic and deliver growth and security.
He is under pressure to reverse years of weak economic growth, and now wants to pitch Britain as a destination for further investment by opting for the light-touch regulation favoured by the United States in areas such as AI, as opposed to the more interventionist approach of the European Union.
The Trump administration has criticised European online safety laws and digital taxes, including those in Britain, but they were not part of the discussions over the pact.
This week, it was also revealed that the Prime Minister's favourability has plunged to the lowest point ever as he attempts to hold power within his own party.