Thames Valley Police said one person died in the large fire at a property in Grovelands Road.
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A man has been arrested on suspicion of murder and arson following a fatal fire in Reading that has left a number of people unaccounted for.
Thames Valley Police said one person died in the large fire at a property in Grovelands Road.
A 31-year-old man has been arrested and remains in custody.
The force said the incident is not being treated as terror-related and urged people to avoid the area, with road closures in place.
In a statement on Twitter, Thames Valley Police said: “Local agencies are working together at the scene of a large fire at a property in Grovelands Road, Reading.
“Our officers, as well as the fire and ambulance services, are at the site. Sadly, one person is believed to have died, and a number of others are unaccounted for.
“Officers have arrested a 31-year-old man on suspicion of arson and murder and he is in custody at this time.”
The statement added: “If you have any concerns, for loved ones, please try and contact them in the first instance. A dedicated number is being set up for this, and details will follow very shortly.”