Pope Leo's brother was forced to evacuate his home following a bomb threat.
John Prevost, the middle brother of Pope Leo XIV, had a bomb threat reported at his New Lenox home, about 30 miles from the centre of Chicago.
Police investigated the home at 6.29pm on Wednesday and found no explosives or hazardous materials.
New Lenox police said surrounding homes were also evacuated "out of an abundance of caution".
Specialised units, including an explosive-detecting K9 unit, were called to assist in the investigation.
In a statement, police said: "After careful examination, investigators determined that the threat was unsubstantiated and that no explosive devices or hazardous materials were present."
But New Lenox police are continuing their investigation in order to find the origin of the false report.
The eldest brother in the Prevost family, Louis, has been praised by Donald Trump for his support of the President.
Pope Leo's middle brother, John Prevost (not pictured), was forced to evacuate after a bomb threat was called to his New Lenox home
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The bomb threat follows a public row between the leader of the Catholic Church and the President.
Pope Leo is currently in Cameroon where he criticised leaders who spend billions on wars and said the world was being "ravaged by a handful of tyrants".
On Thursday he said: "The masters of war pretend not to know that it takes only a moment to destroy. Yet often a lifetime is often not enough to rebuild.
"They turn a blind eye to the fact that billions of dollars are spent on killing, on devastation. The resources needed for healing, education, and restoration are nowhere to be found."
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Pope Leo XIV is currently in Cameroon, where he said the world was being 'ravaged by a handful of tyrants'
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Mr Trump has accused the Pope of being too liberal and "weak on crime" in the public spat.
Earlier this week the President posted an image on Truth Social which seemingly depicted him as Jesus Christ.
He refused to apologise for the image but did delete the image, claiming it depicted him as a doctor, wearing a white robe.
He later posted a second AI image of Jesus Christ embracing the President in front of an American flag.
PICTURED: Louis Prevost, the older brother of Pope Leo, meeting with the President in the Oval Office
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Vice President JD Vance - who has written a book about his conversion to Catholicism - told the Pope to "stick to matters of morality" as he weighed in on the spat.
He told a Turning Point USA event: "When the Pope says that God is never on the side of people who wield the sword, there is more than a 1,000-year tradition of just war theory."
But a statement from the US Conference of Catholic Bishops said Mr Vance mis-stated the Pope's position, saying the Catholic Church teaches "just war theory" and a "nation can only legitimately take up the sword ‘in self-defence, once all peace efforts have failed’".
It added: "When Pope Leo XIV speaks as supreme pastor of the universal Church, he is not merely offering opinions on theology, he is preaching the Gospel and exercising his ministry as the Vicar of Christ."
The first American Pontiff has consistently denounced the Iran war, previously saying the President's remarks he would remove Iran's civilisation as "unacceptable".
On social media, he previously said: "Anyone who is a disciple of Christ, the Prince of Peace, is never on the side of those who once wielded the sword and today drop bombs."