Hundreds of activists are preparing to protest in central London over Trump's State Visit.
More than 1,600 Met police officers will be deployed, including 500 assisting from other forces.
The march, organised by the Stop the Trump Coalition, will begin by 3pm.
They will follow a route down Regent Street, Piccadilly Circus, Haymarket, Cockspur Street, Whitehall, Parliament Street and into Parliament Square, where they will hold a rally until 7pm.
Public Order Act conditions have been imposed to prevent serious disruption to the community.
Donald Trump and First Lady Melania Trump will spend three days in the UK and carry out multiple engagements with members of the Royal Family and the Prime Minister.
The US President will become the first elected leader in modern times to enjoy two UK State Visits.
Trade, Ukraine and Gaza are set to dominate talks between Mr Trump and Sir Keir.
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Hundreds of activists are preparing to protest in central London over Trump's State Visit
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The trans-Atlantic allies are understood to have come to an agreement focused on accelerating the development of nuclear power, with President Donald Trump and the Prime Minister expected to sign the deal this week.
Campaigners are demonstrating against what they call “our Government’s choice to honour a man who is violating human rights in the United States and around the world”.
The group is composed of more than 50 trade unions, charities and interest groups.
It will also feature speeches from the new Green Party leader, Zack Polanski, as well as former Labour leader and Islington North MP Jeremy Corbyn.
They will follow a route down Regent Street, Piccadilly Circus, Haymarket, Cockspur Street, Whitehall, Parliament Street and into Parliament Square
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Security concerns are heightened following the murder of Charlie Kirk, who was shot in the neck during an event at Utah Valley University.
He was a close ally of Mr Trump and has caused an outpouring of grief in the US, including from the President himself, who described the 31-year-old father of two as "Great, and even Legendary".
President Trump is due to stay at Windsor Castle this evening after he lands in the UK and will meet members of the Royal Family on Wednesday.
He is expected to touch down in the UK sometime this evening.
A rally will be held until 7pm in Parliament Square
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Speaking to GB News, security expert Will Geddes explained it will be a "monumental" security operation to maintain the American leader's safety on his three-day trip.
He told the People's Channel: "This is over the next couple of days, going to be a monumental security operation that is going to involve naming many different facets, especially at a time where we're having extremely volatile protests, and certainly in terms of the position of the United Kingdom on the world stage.
"The world will be watching over the next two days as to how well we secure President Donald Trump when he comes to visit. Windsor Castle has been very much fortified. Local residents are almost calling it a fortress.
"There are a lot of protests that have already started amassing around Windsor Castle in terms of security, not only is there Thames Valley Police with the support of the Metropolitan Police, but there are 1,300 troops that are going to be there and 120 odd horses."
Anyone preparing to take part in the Stop the Trump Coalition march must form up in the area shaded on the map below, the Met Poilce has said
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Stephen Doughty, North America minister, insisted that the Prime Minister is "focused on deepening our special relationship with the United States".
Speaking in the Commons, Stephen Doughty said that the "special relationship" is "enduring and will endure for the prosperity and security of our peoples well into the future".
He told MPs: "The Prime Minister and this Government are focused on deepening our special relationship with the United States in the interests of people across the Atlantic, for jobs, for growth, for prosperity, for security, for our defence.
"That relationship with the United States is a relationship that has endured, is enduring, and will endure for the prosperity and security of our peoples well into the future."