Resident doctors are set to go on strike for five days amid an ongoing dispute with Labour over pay.
They will strike from June 15 until June 19, the British Medical Association (BMA) confirmed.
The strike announcement has come after the union's first round of talks with incoming Health Secretary James Murray.
The June walkout will commence from 7am on June 15 and persist until 6.59am on June 19 that week.
The BMA has further warned that Britons could face another round of strikes in July if no progress is made while talks continue with Whitehall.
However, union bosses expressed disappointment that a change of Health Secretary did not trigger a "change in approach".
Dr Jack Fletcher, chairman of the BMA's resident doctors' committee, said: "We had hoped that a change in leadership at the Department of Health and Social Care would lead to a change in approach.
"Sadly, we have run up against the same unwillingness to move we encountered under Mr (Wes) Streeting.
Resident doctors will strike for five days in June
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"We were prepared to give Mr Murray time to settle into his role before completing the work his predecessor left unfinished – to both make a fair and meaningful pay offer and make concrete commitments to end the jobs bottleneck throttling the careers of our colleagues.
"He has not taken it. Instead, we are hearing the same tired line: vagueness on new jobs and no further money on the table.
"We cannot be asked to negotiate in good faith for weeks, only to be told there is nothing left to negotiate about on pay and no further details at this stage on jobs."
Mr Murray, who became Health Secretary just under a fortnight ago, also had hoped to launch a "productive relationship" with the union as he became inducted into the department.
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Mr Murray became Health Secretary after Wes Streeting resigned
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However, the demands were "unrealistic, unaffordable and unsustainable", he said.
Over the past four years, resident doctors have received a 33.4 per cent pay rise, which marks the highest jump anywhere across the public sector.
The Ealing North MP ceded he was "disappointment" the BMA refused to consider ways to "strengthen the deal on the table and have instead rushed once again to unnecessary and unreasonable strike action".
He added: "These are simply not grounds for yet more strike action, which patients do not support, puts further pressure on other staff and costs the NHS hundreds of millions of pounds."
But Dr Fletcher insisted the union's demands were "straightforward" while Mr Murray instructed the BMA to step down from the "damaging" walkout.
The next round of strikes scheduled would be the 16th walkout since 2023, all of which have already cost the taxpayer an eyewatering £3billion.
John O’Connell, Chief Executive of the TaxPayers' Alliance, said: "Taxpayers will be livid that resident doctors are walking out for the 16th time in three years.
"After multiple inflation-busting pay rises and record NHS funding, the BMA is still demanding more despite being offered a deal that would have seen some of them earn six figures."
Mr McConnell urged the Health Secretary to "stand firm and not allow the NHS to be held hostage by union militancy".
Meanwhile, Stuart Andrew MP, the Shadow Health Secretary, hit out at Sir Keir Starmer, blaming the Prime Minister for "failing to get a grip of this crisis".
Mr Andrew added: "Labour does not have the backbone to stand up to the militant BMA, leaving patients to pay the price through more uncertainty yet again.
"As the NHS braces for another round of strikes, it is clear Labour has no plan to protect patients or taxpayers.
"Only the Conservatives are prepared to take the tough decisions by banning doctors' strikes holding the NHS hostage."