Prince Harry has donated nearly £370,000 to projects that support injured children from Gaza and Ukraine through his foundation, the duke's office confirmed on Wednesday.
The donation will contribute to the World Health Organisation's (WHO) efforts with evacuations and the development of prosthesis.
Wednesday's announcement came on the third day of the prince's visit to Britain as Harry visited the Centre for Injury Studies (CIS), part of Imperial College London.
The Duke of Sussex was visiting the CIS to learn more about its recent work on remedying injuries suffered by children and those sustained in natural disasters.
Prince Harry has donated almost £370,000 through his Archewell Foundation to causes supporting Gaza and Ukraine
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The Duke's donation in full amounted to $500,000 (£368,894.79).
"No single organisation can solve this alone," the Duke declared in a statement.
"Gaza now has the highest density of child amputees in the world and in history.
"It takes partnerships across government, science, medicine, humanitarian response and advocacy to ensure children survive and can recover after blast injuries," he added.
Prince Harry toured the Centre for Injury Studies (CIS), part of Imperial College London, with WHO chief Tedros Adhanom Ghebreyes
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The donation was delivered in three grants from Harry and his wife Meghan's Archewell Foundation include $200,000, £147,584, to the World Health Organisation efforts to facilitate medical evacuations from Gaza to Jordan.
$150,000 (£110,711) was also given to the Save the Children charity for their ongoing humanitarian support in Gaza.
The third grant of $150,000 (£110,711) was awarded to the Centre of Blast Injury Studies, part of CIS, to support the development of prostheses for use by injured children, with the ongoing conflicts in Ukraine and Gaza in mind.
Prince Harry has a long been associated with the Centre for Blast Injury Studies, which was set up with a focus on helping military veterans and personnel in 2013.
'No single organisation can solve this alone,' Harry said on the situation in Gaza
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Emily Mayhew, the paediatric blast injury lead at Imperial College London, celebrated the Duke's involvement in their project.
"We very much consider you part of our story," she told him upon his arrival.
The duke was joined WHO chief Tedros Adhanom Ghebreyes for a tour of the CIS, where they met double leg amputee Dave Henson, a CIS ambassador, who has known Harry for more than a decade and was the first captain of the British Invictus team in 2014.
Mr Henson, who lost his legs to an explosion in Afghanistan in 2011, also expressed his thankfulness for Harry's involvement.
During his visit, Harry met recipients of some of the CIS's state of the art prosthesis
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"It's been hugely important for raising the profile of the centre," he said.
While at the CIS, Harry was shown were new designs for prosthetic knee joints for children, including a demonstration of the world’s most advanced foot and ankle physiological simulator.
He also visited the "gait lab" which uses a virtual reality technology with motion capture cameras and a treadmill to test the effectiveness of new prosthetic designs on patients.
"Here's a good looking man," Harry grinned when seeing veteran Steve Arnold demonstrate the gait lab equipment.
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Prince Harry's donation will support evacuation efforts and further development of life changing prosthesis
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Mr Arnold, who also lost both his legs in an IED blast ion Afghanistan in 2011, was previously antiquated with the duke - having competed in the 2014 and 2017 Invictus Games as a cyclist.
"It's massive help", he glowed about Harry's visit.
Mr Arnold hoped the duke's aid would ensure that children and others got the same level of support he had received since his injury and "get better with whatever disability they have".
The CIS revealed the troubling statistics that children were seven times more likely to die from blast injuries than adults.
As a result, with support from Save the Children, they began expanding their work to launch the Centre for Paediatric Blast Injury Studies in 2023.