Sir Keir Starmer has lost a third aide since Labour romped to victory in the 2024 General Election.
Nin Pandit is expected to leave her role as Prime Minister’s personal private secretary, joining Sir Keir's former Chief of Staff Sue Gray and communications chief Matthew Doyle out of No10.
Ms Pandit was lured over to No10 after serving as a senior aide to the chief executive of the National Health Service last October.
However, the Prime Minister was said to have become increasingly frustrated about her being ineffective in the role and is now expected to move her to another position in Downing Street.
Baroness Gray left No10 less than 100 days into Sir Keir's premiership, effectively being reshuffled into the House of Lords to briefly undertake the role of envoy for the nations and regions.
Meanwhile, Mr Doyle stood down in March amid growing criticisms of Downing Street's media operation.
Following Ms Pandit's departure, experienced No11 official Dan York-Smith is expected to move into the position of the Prime Minister's personal private secretary to improve No10's economic expertise.
However, no official appointments have yet been announced by Downing Street to confirm any changes.
Sir Keir Starmer is expected to conduct a wider No10 reshuffle soon
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However, Sir Keir is expected to make further changes as early as next week, No10 insiders have told The Guardian.
Despite speculation of major changes inside No10, Chris Wormald is reportedly safe in his role as Cabinet Secretary.
The expected changes come as Sir Keir's ratings continue to tank following the 2024 General Election.
A recent Find Out Now poll had Labour on just 18 per cent, significantly behind Reform UK on 34 per cent.
Sue Gray resigned due to the "intense commentary" around her position | GETTY
Nigel Farage's party is also now consistently leading in the opinion polls, with Find Out Now's becoming the 92nd consecutive survey putting Reform UK in first-place.
No11 has also been conducting a major shake-up ahead of Rachel Reeves's crunch second Budget.
Pensions Minister Torsten Bell is said to have been given a greater hand in preparing for the fiscal statement.
The Chancellor has been warned that she faces a black hole in public finances of around £50billion, with No11 expected to consider raiding the pockets of Britain's wealthiest to cover the books.
Labour MP calls for Keir Starmer to sack Attorney General Lord HermerHowever, Sir Keir is also facing pressure from a veteran Labour MP to sack his Attorney General Lord Hermer.
Lord Hermer, a long-time friend of the Prime Minister, faced fury earlier this year after appearing to compare those advocating for Britain to leave the European Convention on Human Rights to Nazis.
Speaking earlier this week, Mr Stringer said: “I don’t think that the Attorney General should ever have been appointed in the House of Lords.
“He’s got no democratic experience, I think particularly when he’s making such big decisions, demanding every law basically goes before him, he’s spent billions of pounds on the Chagos Islands – the Attorney General should be in the House of Commons, so in that sense, yes.
Tulip Siddiq and Louise Haigh have both resigned from the Government since Sir Keir Starmer came to power
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“It’s both the accountability … and the particular policies this Attorney General is pursuing.”
While the Prime Minister has purged a number of left-wing rebels from his party before the summer recess, Sir Keir has also had to endure multiple departures from his frontbench.
Louise Haigh was forced to quit as Transport Secretary in November last year after she admitted to pleading guilty to misleading the police a decade ago.
Meanwhile, Tulip Siddiq stepped down as Anti-Corruption Minister in January after she inadvertently misled the public.
No10 declined to comment on Ms Pandit departure when approached by GB News.
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