Meghan and Harry are going to Manchester on Monday for the One Young World summit, an event which brings together young leaders from more than 190 countries.
Meghan, a counsellor for the organisation, will give a keynote address at the opening ceremony.
The Sussexes will also meet a group of summit delegates doing “outstanding work on gender equality”, One Young World said.
The trip comes just days after Meghan’s wide-ranging interview with The Cut magazine in which she said it takes “a lot of effort” to forgive and hinted that she can “say anything”.
The former Suits actor said that “just by existing” she and Harry were “upsetting the dynamic of the hierarchy” before they stepped down as senior working royals in 2020.
After Manchester, the Sussexes will travel to Germany for the Invictus Games Dusseldorf 2023 One Year To Go event which is taking place on Tuesday.
They will then return to the UK for the WellChild Awards in London where Harry will deliver a speech on Thursday.
Their visit to the UK will be the first time they have been back in the country since the Jubilee celebrations in early June, when they attended the service of thanksgiving at St Paul’s Cathedral.
The trip falls in the same week the country's new prime minister is due to be announced and asked to form a government by the Queen.
The monarch will appoint a new prime minister at Balmoral for the first time in her reign.
The 96-year-old, who has faced ongoing mobility issues, traditionally holds audiences with outgoing and incoming premiers at Buckingham Palace.
It is not known whether Meghan and Harry will visit the Queen in Balmoral during their trip.
Security will no doubt be at the forefront of Harry’s mind as he travels from his home in California for the high-profile appearances.
He is bringing legal action over a decision not to allow him to pay for police protection for himself and his family when in the UK.
This summer he won a bid to bring a High Court claim against the Home Office.
His challenge concerns the February 2020 decision of the Executive Committee for the Protection of Royalty and Public Figures (Ravec) over his security, after being told he would no longer be given the “same degree” of personal protective security when visiting.
The Royal Family has been bracing itself for Harry’s forthcoming tell-all book, which he has vowed will be an “accurate and wholly truthful” account of his life.
The memoirs were expected to be published in late 2022 by Penguin Random House but a release date has yet to be confirmed.
Meghan Markle and Prince Harry Daniel Leal-Olivas
Meghan will make a speech in Manchester on Monday BRENDAN MCDERMID