Bob Weir, who helped found the Grateful Dead, has died at 78.
The guitarist passed away after fighting cancer and lung problems, his Instagram account confirmed in a statement on Sunday.
He died peacefully with family by his side.
"There is no final curtain here, not really. Only the sense of someone setting off again," the post read.
"He often spoke of a three-hundred-year legacy, determined to ensure the songbook would endure long after him," the post continues.
"May that dream live on through future generations of Dead Heads."
His wife Natascha and daughters Shala and Chloe requested privacy - while thanking fans for their decades of support.
Weir's career stretched across more than 60 years.
PICTURED: Bob Weir plays an electric guitar with the Grateful Dead as he performs onstage at Nassau Coliseum in 1979
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His breakthrough came in 1965 when he founded the legendary psych-rock band.
The group quickly became central to San Francisco's counterculture scene and helped pioneer the jam band genre.
Their sound mixed psychedelia with folk and Americana influences.
Recognition followed with Rock and Roll Hall of Fame induction in 1994 - while the Grammys honoured them with a Lifetime Achievement Award in 2007.
The original band ended in 1995 when co-founder Jerry Garcia died, though Weir remained active through various successor projects, including Dead & Company, which held a residency at the Las Vegas Sphere in 2024 and 2025
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PICTURED: Phil Lesh, Bob Weir and Jerry Garcia perform in California in 1984
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Weir received his cancer diagnosis in July, but kept performing even while undergoing treatment.
"Those performances, emotional, soulful, and full of light, were not farewells, but gifts," the post says. "Another act of resilience. An artist choosing, even then, to keep going by his own design."
His specific type of cancer was never disclosed - though he overcame the disease before his death, according to the Instagram statement.
Fellow musicians paid tribute on Saturday night.
Tributes poured in through Saturday night into Sunday for the psych-rock icon
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Guns N' Roses guitarist Slash shared a photo of Weir performing, writing "RIP" alongside a broken-heart emoji.
"I first saw Bob at Woodstock with the Grateful Dead and was blown away by that whole band, and the musicianship," former Eagles guitarist Don Felder said on Instagram with a photo of himself with Weir.
"I feel so blessed to have been able to have him sing on 'Rock You' from American Rock and Roll. Until we meet again, amigo."
And in tribute, New York City's Empire State Building lit up in tie-dye to honour his passing.